Product Overview

AFFINIX Series

QCM apparatus that quantifies changes in physical properties and intermolecular interactions, the AFFINIX Series.
The AFFINIX Series is a group of apparatus that uses QCM to visualise molecular recognition and the changes caused by subsequent reactions by detecting mass changes at the nano level.

AFFINIX Series

Key points for product selection

AFFINIX Q8AFFINIX QN ProAFFINIX QNμAFFNIX QN
Installation of a simple and easy interaction analyzer
Measurement of coupling constant and rate constant
Reduction of the consumption of samples
High number of samples to be measured
Organic solvent present in test solution
Immobilization using organic solvents○**○*○*
Quantitative determination of the viscoelasticity of adsorbates
Quantitative determination of the viscosity of the solution

*Please use crystal separated sensor type
**Please remove the measuring cup before use
◎ : Especially recommended   ○ : Recommended   △ : Not very suitable   - : Unmeasurable

AFFINIX Series

Applications

Intermolecular Interaction Analysis(Bio and Materials related)

・Quantifying interactions between substances in real-time and label free
・Affinity and kinetics (Kd, Ka, kon, koff) analysis of interactions between molecules
・Measurement of complex multimolecular interactions
・Establishment of experimental conditions and preliminary considerations
・Quantification of bound substance, detection of interactions in crude solution
・Quantification of adsorbed molecules on surface

Protein RelatedDNA RelatedSugar Chain Related
Protein-protein interactions
Antigen-antibody reactions
β-Amyloid etc. aggregation reactions
Analysis of protein complex formation
Cofactor search
Hybridisation
Detection of mismatched base pair
RNA related reactions
Transcription factor search
Evaluation of antibiotics and hybrid inhibitors
Glyco-lectin interactions
Sugar-binding proteins
Chitin/chitosan binding
[Application notes]
Self aggregation of Prion reactions
[Application notes]
Analysis of DNA Elogation Reaction
DNA-Hybridization-Inhibiting Metal Complex
Lipid RelatedOxygen ReactionsBinding of Small Molecules
Reaction of lipid membrane and antimicrobial peptide
Surface treatment and ribosome binding
Adsorption of catechins to lipid membrane
Decomposition reaction by Dnase
Decomposition reaction by trypsin
Extension reaction by DNA polymerase
Hydrolysis reaction on sugar chain
Sugar chain lengthening reaction
Evaluation of inhibitors
Evaluation of drug binding
Ligand-receptor interactions
Evaluation of bonding between small molecules
Evaluation of toxin
[Application notes]
Adsorption of Liposome to Peptide
Binding of Pharmaceutical Small Molecules an T7 Phage
Application Examples (Biology)Special SensorEvaluation of Organic Polymers
Selection of highly effective oxygen detergent
Antibody reagent degradation test
Determination of meat maturity
Determination of blood type from trace body fluid
Selection sensor blocking agent
Metal surface sensor (Ti, Ni, Al, etc.)
Metal oxide surface sensor (SiO2 etc.)
Adsorption of microparticles to polymers
Adsorption to latex beads
Evaluation of polymer solubility
Molecular adsorption to biocompatible membranes
[Application notes]
Detection of Verotixin
Evaluation of Inorganic MaterialsAtmospheric MeasurementsApplication Examples (Material)
Adsorption to carbon nanotubes
Adsorption to fullerene
Adsorption to metal nanocolloid
Adsorption to hydroxyapatite
Evaluation of metal surfaces solubility
Effects of light irradiation treatment
Adsorption of smoke particles
Odour sensor
Evaluation of dirt adsorption to coating agent
Determination of optimum use amount of detergent
Evaluation of antifouling agent
Dye adsorption on cotton
Determination of optimum conditions for substrate fabricatio

Viscoelasticity Analysis  

・Nano level viscoelasticity analysis of the surface or the interface of adsorbed layer
・Calculation of viscoelasticity parameters (G’, G”, tanδ etc.)
・Measurement of viscoelastic changes associated with molecular recognition of biomolecules
・Evaluation of surface physical properties such as swelling and viscoelasticity of adsorption film
・Microviscosity measurement of polymer solutions and high-concentration protein solutions
・Viscoelasticity analysis of hardening, solidification, and phase transition processes of materials

Viscoelasticity analysis of adsorbed filmStructural change of adsorption filmMeasurement during liquid temperature change
Viscoelasticity analysis of protein-protein interaction
Viscoelasticity analysis of DNA, sugar-chain and lipid
Observation of film hardness change due to binding
Observation of structural change of temperature responsive polymer
Observation of structural change of protein
Adsorption behaviour of lipids or ribosomes on solid surfaces
Observation of cloud point of surfactant
Viscoelasticity observation of biocompatible polymers
Monitoring of liquid crystal, gel phase transition
Viscoelasticity analysisUltra trace measurementSeparate measurement of mass and viscosity
Viscoelasticity analysis of soft material (colloid, macromolecule etc.)
Monitoring of gelation process
Viscoelasticity analysis of adhesive, resin, grease etc.
Adsorption measurement of rare samples
Viscosity measurement of Newtonian fluid
Viscoelasticity measurement of high concentration protein
Evaluation of drug dissolved in organic solvent
Adsorption measurement of sample dissolved in glycerol
Interaction measurement of proteins in crude solutio
AFFINIX Series

Specifications

ItemAFFINIX QNAFFINIX QN μ(Micro)AFFINIX QN ProAFFINIX Q8
ModelQCM2008-STKITQCM2008-LVKITQCM2008-PRKITQCM2012(Standard Model)/ QCM2012E(Limited Function Model)
Measurement Principle・SystemQuartz Crystal Microbalance(QCM) oscillationQuartz Crystal Microbalance(QCM) oscillationQuartz Crystal Microbalance (QCM)
・ Admittance Analysis Methods
Quartz Crystal Microbalance(QCM) oscillation
Measurement Frequency・Sensiticity27MHz(Fundamental frequency)
30pg/Hz
27MHz(Fundamental frequency)
30pg/Hz
27MHz (Fundamental) ・ 30pg/Hz
81MHz (Overtone) ・ 10pg/Hz
27MHz(Fundamental frequency)
30pg/Hz(620pg/cm2・Hz)
Dynamic Range100pg(per sensor)100pg(per sensor)100pg~10μg100pg~10μg(2ng/cm2~200μg/cm2)
Oscillation StabilityNoise ≦ 1 Hz(distilled water, 25℃, at stable state)Noise ≦ 2 Hz(27MHz, distilled water, 25℃, at stable state)Noise ≦ 2 Hz(27MHz, distilled water, 25℃, at stable state)Noise ≦ 1 Hz(27MHz, distilled water, 25℃, at stable state)
Average Drift≦ 1 Hz/min(distilled water, 25℃, at stable state)≦ 1 Hz/min(distilled water, 25℃, at stable state)≦ 1 Hz/min (27MHz, distilled water, 25℃, at stable state)≦ 1 Hz/min(distilled water, 25℃, at stable state)
Injection SystemManual, Multiple injection is possibleManual, Multiple injection is possibleManual, Multiple injection is possibleManual, Multiple injection is possible
Min. Injection Volume0.1μL~ (dependent on micropipette to be used)0.1μL~ (dependent on micropipette to be used)0.1μL~ (dependent on micropipette to be used)0.1μL~ (dependent on micropipette to be used)
Channel Number1118
Cup VolumeGlass cell[5~11mL]※Consumable mini cell[1.6mL]400~550μL400~550μL80~120μL
Sensor TypeCeramic sensor chipSensor cellSensor Cup (specific for QN Pro)Sensor with a removable cup
Stir MethodMagnetic StirrerMagnetic StirrerMagnetic StirrerStirrers driven by motors
0~3,000rpm(setting step:100rpm)
3,000 rpm(fixed)
Temp. Control SystemPeltierPeltierPeltierPeltier
Setting Temperature0.1~50.0℃(step:0.1℃)10.0~50.0℃(step:0.1℃)10.0~60.0℃(step:0.1℃)10.0~40.0℃(step:0.1℃)
※Range appliable to standard model only with minimum set temp. 10℃ below room temp.
※※25℃ fixed for Limited Function Model
System SoftwareMeasuring software
(PC limited license pre-installed in provided PC, there is no installer disc)
Install-free data viewer software included by default in CD
Measuring software
(PC limited license pre-installed in provided PC, there is no installer disc)
Install-free data viewer software included by default in CD
Measuring software:『AFFINIX QN Pro』
(PC limited license pre-installed in provided PC, there is no installer disc)
Data viewer software:『AFFINIX QN Pro Viewer』
(The installer is saved in PC and an additional disc)
Measuring software
(PC limited license pre-installed in provided PC, there is no installer disc)
Install-free data viewer software included by default in CD
Date Processing PartWindows Laptop PCWindows Laptop PCWindows Laptop PCWindows Laptop PC
Communication SystemEthernet Virtual serialEthernet Virtual serialEthernet Virtual serial
PC|card
Ethernet Virtual serial
Output parameters--Fs,F2,Fw,Q,D,R,(C0,C1,L1)-
Operating Environment20~30℃(Recommended)20~30℃(Recommended)20~30℃(Recommended)20~30℃(Recommended)
Size140W×350D×220H(mm)140W×350D×220H(mm)140W×300D×220H(mm) (AFFINIX QN main unit)
71W×360D×144H(mm) (Analysing unit)
220W×410D×170H(mm) (AFFINIX Q8 main unit)
Weight7.7kg7.1kg9.0kg7.0kg (Affinix Q8 main unit only)
Power SupplyAC 100~240V, 1AAC 100~240V, 1AAC 100~240V, 3A (Body:1A, Analyzing Unit:2A)AC 100~240V, 1A (Affinixx Q8 main unit only)
Optional accessoryData Analysis Software AFFINIX Q User Analysis (AQUA) Installer CDData Analysis Software AFFINIX Q User Analysis (AQUA) Installer CDData Analysis Software(AQUA)Data Analysis Software AFFINIX Q User Analysis (AQUA) Installer CD
Standard itemsAFFINIX QN Base Equipment(1) Software included PC(1) PC accessories(with LAN Cable)(1) Glass cell(1) Stirrer(1) USB memory stick(1) Sensor chips(4 in a case) Instruction Manual(1) Data Viewer(1)AFFINIX QNμ Base Equipment(1) Software included PC(1) PC accessories(with LAN Cable)(1) Cell cover with stirrer(1) USB memory stick(1) Sensor cells(4 in a case) Instruction Manual(1) Data Viewer(1)AFFINIX QN Pro Base Equipment(1) Communication / Measurement Kit(1) Measurement Control Software included PC(1) PC accessories(with LAN Cable)(1) Instruction Manual(1) Cell Cover with Stirring Bar(1) USB memory stick(1) Sensor cups(4 pieces/case(1)) Calibration Set(1) Data Viewer(1)AFFINIX Q8 Base Equipment(1) Software included PC(1) PC accessories(with LAN Cable)(1) Instruction Manual(1) Sensor holder(1) Sensor tray sensor pack(8 in a set) Data Viewer(1)
PC Spec.PC with pre-installed measurement softwarePC with pre-installed measurement softwarePC with pre-installed measurement softwarePC with pre-installed measurement softwa
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